The MEGASTROKE consortium, a large-scale international collaboration launched by the International Stroke Genetics Consortium, releases the summary statistics from the 2018 meta-analysis of Genome-wide Association (GWA) data in stroke and stroke subtypes to enable other researchers to explore these data for scientific purposes. The files include P-values, betas, and standard errors at all SNPs represented in MEGASTROKE.

We provide results for the following two meta-analyses as detailed in the original MEGASTROKE publication (Malik et al., Nat Genet, 2018).

(1) a fixed-effects meta-analysis restricted to Europeans (40,585 cases; 406,111 controls).
(2) a fixed-effects trans-ethnic meta-analysis including all samples (67,162 cases; 454,450 controls).

Results for any stroke and for stroke subtypes are presented in separate files:
(1) any stroke = AS
(2) any ischemic stroke = AIS
(3) large artery stroke = LAS
(4) cardioembolic stroke = CES
(5) small vessel stroke = SVS

Each file contains the following information:

MarkerName: SNP rsID or chromosome:position if rsID not available
Allele1: Effect allele (coded allele)
Allele2: Non effect allele (non coded allele)
Freq1: Effect allele frequency
Effect: Overall estimated effect size for the effect allele
StdErr: Overall standard error for effect size estimate
P-value: Meta-analysis P-value using regression coefficients (beta and standard error)

We present results for SNPs passing the MEGASTROKE filters (n_cases > 50% and oevar_imp > 0.5). SNPs not passing these filters are not shown.

1) Any publications utilizing MEGASTROKE data should include the following:

Acknowledgments
Please include the following sentence: “The MEGASTROKE project received funding from sources specified at http://www.megastroke.org/acknowledgments.html"
Please list all MEGASTROKE authors appearing in the main author byline in the supplementary material of your manuscript.

References
Your manuscript (main text) should cite the following reference:
Malik et al. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes, Nature Genetics, 2018, 50 : 524-537. doi:10.1038/s41588-018-0058-3 [PubMed ID: 29531354]

2) The following secondary use of MEGASTROKE data is not authorized:
Data should not be used for research into the genetics of intelligence, education, social outcomes such as income, or potentially sensitive behavioral traits such as alcohol or drug addictions.